ADM2蛋白 (Intermedin) [剪切为：肾上腺髓质素-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)]
ADM2蛋白 (Intermedin) [剪切为：肾上腺髓质素-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)]
Q7Z4H4功能描述
Intermedin/ADM2是一种肽类激素，作为由CALCRL-RAMPs受体复合物介导的胃肠道和心血管生物活性的生理调节因子发挥作用 (PubMed:14615490)。通过与CALCRL-RAMP3受体复合物相互作用激活cAMP依赖途径 (PubMed:14615490)。 {ECO:0000269|PubMed:14615490}。
组织特异性
Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.
亚细胞定位
Secreted
关键词