粘附G蛋白偶联受体G2 (G蛋白偶联受体64) (人类附睾特异性蛋白6) (He6) [剪切为: 粘附G蛋白偶联受体G2，N端片段 (ADGRG2 N端片段); 粘附G蛋白偶联受体G2，C端片段 (ADGRG2 C端片段)]
粘附G蛋白偶联受体G2 (G蛋白偶联受体64) (人类附睾特异性蛋白6) (He6) [剪切为: 粘附G蛋白偶联受体G2，N端片段 (ADGRG2 N端片段); 粘附G蛋白偶联受体G2，C端片段 (ADGRG2 C端片段)]
Q8IZP9功能描述
粘附G蛋白偶联受体 (aGPCR)，作用于类固醇激素，如脱氢表雄酮 (DHEA；亦称为3beta-羟基雄甾-5-烯-17-酮) 和雄烯二酮 (PubMed:29393851, PubMed:35982227, PubMed:39884271)。参与控制附睾功能和雄性生育力的信号转导通路 (PubMed:29393851)。配体结合引起构象改变，从而通过鸟苷酸结合蛋白 (G蛋白) 触发信号传导，并调节下游效应子（如腺苷酸环化酶）的活性 (PubMed:33303626, PubMed:34234254)。ADGRG2与G(s) G蛋白偶联，并介导腺苷酸环化酶活性的激活 (PubMed:29393851, PubMed:34234254)。在体外也能与G(q) G蛋白偶联 (PubMed:29393851)。与CFTR一起，是促进输出小管内液体重吸收所必需的 (PubMed:29393851)。 {ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:33303626, ECO:0000269|PubMed:34234254, ECO:0000269|PubMed:35982227, ECO:0000269|PubMed:39884271}。
组织特异性
Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.
亚细胞定位
Apical cell membrane
关键词