粘附G蛋白偶联受体E5 (白细胞抗原CD97) (CD抗原CD97) [裂解为：粘附G蛋白偶联受体E5亚基α；粘附G蛋白偶联受体E5亚基β]
粘附G蛋白偶联受体E5 (白细胞抗原CD97) (CD抗原CD97) [裂解为：粘附G蛋白偶联受体E5亚基α；粘附G蛋白偶联受体E5亚基β]
P48960功能描述
受体，可能参与白细胞激活后早期的粘附和信号传导过程。在白细胞迁移中起重要作用。 {ECO:0000250|UniProtKB:Q9Z0M6}。
组织特异性
Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
亚细胞定位
Cell membrane
关键词