ADGRB2 O60241

粘附G蛋白偶联受体B2 (脑特异性血管生成抑制剂2)

蛋白质信息 (UniProt)

粘附G蛋白偶联受体B2 (脑特异性血管生成抑制剂2)

O60241

功能描述

孤儿G蛋白偶联受体，参与细胞粘附，可能参与细胞间相互作用。通过G蛋白GNAZ激活NFAT信号通路，一种转录因子 (PubMed:20367554, PubMed:28891236)。参与血管生成抑制 (By similarity)。 {ECO:0000250|UniProtKB:Q8CGM1, ECO:0000269|PubMed:20367554, ECO:0000269|PubMed:28891236}。

组织特异性

Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteoglycan

外部链接

UniProt: O60241

NCBI Gene

GeneCards