ADCYAP1R1 P41586

垂体腺苷酸环化酶激活多肽I型受体 (PAC1 receptor) (PAC1R) (PACAP I型受体) (PACAP-R-1) (PACAP-R1)

蛋白质信息 (UniProt)

垂体腺苷酸环化酶激活多肽I型受体 (PAC1 receptor) (PAC1R) (PACAP I型受体) (PACAP-R-1) (PACAP-R1)

P41586

功能描述

由神经肽垂体腺苷酸环化酶激活多肽 (ADCYAP1/PACAP) 激活的G蛋白偶联受体 (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145)。结合PACAP27和PACAP38生物活性肽 (PubMed:32047270, PubMed:35477937, PubMed:36385145)。配体结合引起构象变化，通过鸟苷酸结合蛋白 (G蛋白) 触发信号传导并调节下游效应器的活性。激活cAMP依赖途径 (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145)。可能调节促肾上腺皮质激素、黄体生成素、生长激素、催乳素、肾上腺素和儿茶酚胺的释放。可能在精子发生和精子活力中发挥作用。引起胃肠道的平滑肌松弛和分泌 (PubMed:32047270, PubMed:33715378)。 {ECO:0000269|PubMed:32047270, ECO:0000269|PubMed:33715378, ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145}。

组织特异性

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

亚细胞定位

Cell membrane; Multi-pass membrane protein

关键词

3D-structure Alternative splicing Cell membrane Developmental protein Differentiation Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein

外部链接

UniProt: P41586

NCBI Gene

GeneCards