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ADCY10 Q96PN6

腺苷酸环化酶10型 (EC 4.6.1.1) (AH相关蛋白) (腺苷酸环化酶同源蛋白) (生殖细胞可溶性腺苷酸环化酶) (hsAC) (sAC) (睾丸可溶性腺苷酸环化酶)

蛋白质信息 (UniProt)

腺苷酸环化酶10型 (EC 4.6.1.1) (AH相关蛋白) (腺苷酸环化酶同源蛋白) (生殖细胞可溶性腺苷酸环化酶) (hsAC) (sAC) (睾丸可溶性腺苷酸环化酶)

Q96PN6

功能描述

催化信号分子cAMP的形成 (PubMed:12609998, PubMed:15659711, PubMed:24567411, PubMed:24616449, PubMed:25040695)。可能作为传感器发挥作用,介导对细胞碳酸氢盐和CO(2)水平变化的反应 (PubMed:15659711, PubMed:17591988)。在哺乳动物精子发生中起关键作用,通过产生cAMP来调节对附睾中精子成熟必不可少的cAMP响应性核因子。诱导获能,即精子在受精前经历的成熟过程 (By similarity)。参与纤毛摆动调节 (PubMed:17591988)。 {ECO:0000250|UniProtKB:Q8C0T9, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988, ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0000269|PubMed:25040695}。

组织特异性

Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing ATP-binding cAMP biosynthesis Cell membrane Cell projection Cytoplasm Cytoskeleton Lyase Magnesium