乙酰辅酶A羧化酶2 (EC 6.4.1.2) (ACC-beta)
乙酰辅酶A羧化酶2 (EC 6.4.1.2) (ACC-beta)
O00763功能描述
线粒体酶，催化乙酰-CoA羧化生成丙二酰-CoA，在脂肪酸代谢中起核心作用 (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583)。催化两步反应，首先是生物素羧基载体（BCC）结构域所携带生物素的ATP依赖性羧化，随后将羧基从羧化生物素转移至乙酰-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583)。通过产生丙二酰-CoA在线粒体处变构抑制肉碱棕榈酰转移酶1，从而负向调节脂肪酸氧化 (By similarity)。与其参与脂肪酸从头合成的细胞质同工酶ACACA一起，促进脂质储存 (By similarity)。 {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}。
组织特异性
Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759).
亚细胞定位
Mitochondrion
关键词