ATP结合盒亚家族G成员8 (EC 7.6.2.-) (固醇蛋白-2)
ATP结合盒亚家族G成员8 (EC 7.6.2.-) (固醇蛋白-2)
Q9H221功能描述
ABCG5和ABCG8形成专性异二聚体，介导跨越细胞膜的Mg(2+)和ATP依赖性固醇转运。在膳食胆固醇进出肠上皮细胞的选择性转运以及肝脏将固醇选择性排泄到胆汁中发挥重要作用 (PubMed:11099417, PubMed:11452359, PubMed:15054092, PubMed:27144356)。正常的固醇稳态所必需 (PubMed:11099417, PubMed:11452359, PubMed:15054092)。与ABCG5形成的异二聚体具有ATP酶活性 (PubMed:16893193, PubMed:20210363, PubMed:27144356)。 {ECO:0000269|PubMed:11099417, ECO:0000269|PubMed:11452359, ECO:0000269|PubMed:15054092, ECO:0000269|PubMed:16893193, ECO:0000269|PubMed:27144356}。
组织特异性
Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359). Low expression levels in the small intestine and colon (PubMed:11099417). Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359).
亚细胞定位
Cell membrane
关键词