ABCG5 Q9H222

ATP结合盒亚家族G成员5 (EC 7.6.2.-) (Sterolin-1)

蛋白质信息 (UniProt)

ATP结合盒亚家族G成员5 (EC 7.6.2.-) (Sterolin-1)

Q9H222

功能描述

ABCG5和ABCG8形成专性异源二聚体，介导依赖Mg(2+)和ATP的固醇跨细胞膜转运 (PubMed:27144356)。在膳食植物固醇和胆固醇进出肠细胞的选择性转运，以及肝脏将固醇选择性排泄到胆汁中起重要作用 (PubMed:11099417, PubMed:11138003, PubMed:15054092, PubMed:27144356)。是正常固醇稳态所必需的 (PubMed:11099417, PubMed:11138003, PubMed:15054092)。与ABCG8形成的异源二聚体具有ATP酶活性 (PubMed:16893193, PubMed:20210363, PubMed:27144356)。 {ECO:0000269|PubMed:11138003, ECO:0000269|PubMed:15054092, ECO:0000269|PubMed:16893193, ECO:0000269|PubMed:20210363, ECO:0000269|PubMed:27144356, ECO:0000303|PubMed:11590207, ECO:0000305|PubMed:11099417}。

组织特异性

Strongly expressed in the liver, lower levels in the small intestine and colon.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing ATP-binding Cell membrane Disease variant Glycoprotein Lipid transport Magnesium Membrane Metal-binding

外部链接

UniProt: Q9H222

NCBI Gene

GeneCards