ABCC4 O15439

ATP结合盒亚家族C成员4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT相关ABC转运蛋白) (多特异性有机阴离子转运蛋白B) (MOAT-B) (多药耐药相关蛋白4)

功能描述

ATP结合盒(ABC)家族的ATP依赖性转运蛋白，主动将生理化合物和异生物质从细胞中排出(PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312)。转运一系列在细胞通讯和信号传导中起关键作用的内源性分子，包括环核苷酸如环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)、胆汁酸、类固醇结合物、尿酸盐和前列腺素(PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430, PubMed:38886124, PubMed:40138312)。也介导谷胱甘肽结合物如白三烯C4 (LTC4)和白三烯B4 (LTB4)的ATP依赖性外排。GSH的存在是LTB4的ATP依赖性转运所必需的，而LTC4的转运不需要GSH (PubMed:17959747)。介导胆汁酸与还原型谷胱甘肽(GSH)的协同转运(PubMed:12523936, PubMed:12883481, PubMed:16282361)。转运广泛的药物及其代谢物，包括抗癌、抗病毒和抗生素分子(PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232)。赋予对甲氨蝶呤等抗癌药物的耐药性(PubMed:11106685)。 {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430, ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312}。

组织特异性

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes.

亚细胞定位

Basolateral cell membrane