ATP结合盒亚家族B成员5 (ABCB5 P-gp) (P-糖蛋白 ABCB5) (EC 7.6.2.2)
ATP结合盒亚家族B成员5 (ABCB5 P-gp) (P-糖蛋白 ABCB5) (EC 7.6.2.2)
Q2M3G0功能描述
能量依赖性外排转运蛋白，负责减少多药耐药细胞中的药物积累 (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008)。特异性存在于角膜缘干细胞中，在角膜发育和修复中起关键作用 (By similarity)。 {ECO:0000250|UniProtKB:B5X0E4, ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}。
组织特异性
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
亚细胞定位
Cell membrane
关键词