ABCA7 Q8IZY2

磷脂转运ATP酶 ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP结合盒亚家族A成员7) (自身抗原SS-N) (巨噬细胞ABC转运蛋白)

功能描述

催化特定磷脂从膜的细胞质侧向胞外/腔内侧的转位，该过程偶联ATP的水解 (PubMed:24097981)。优先转运磷脂酰丝氨酸而非磷脂酰胆碱 (PubMed:24097981)。在脂质稳态和巨噬细胞介导的吞噬作用中发挥作用 (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415)。结合APOA1，可能参与载脂蛋白介导的细胞磷脂外排 (PubMed:12917409, PubMed:14570867, PubMed:14592415)。也可能介导胆固醇外排 (PubMed:14570867)。可能在角质形成细胞分化过程中调节细胞神经酰胺稳态 (PubMed:12925201)。参与脂筏组织以及胸腺细胞和抗原呈递细胞上的CD1D定位，这在自然杀伤T细胞发育和激活中起重要作用 (By similarity)。在巨噬细胞吞噬凋亡细胞中发挥作用 (By similarity)。APOA1或APOA2刺激巨噬细胞吞噬，可能是通过稳定ABCA7 (By similarity)。也参与小胶质细胞和巨噬细胞对淀粉样蛋白-β的吞噬清除 (By similarity)。通过在淀粉样蛋白-β A4前体蛋白 (APP) 内吞和/或加工调节中发挥作用，进一步限制淀粉样蛋白-β的产生 (PubMed:26260791)。淀粉样蛋白-β是阿尔茨海默病患者脑内淀粉样斑块的主要成分 (PubMed:26260791)。 {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}.

组织特异性

Expressed in leukocytes (at protein level) (PubMed:10873640). Widely expressed (PubMed:10873640). Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow (PubMed:10873640, PubMed:11435699). Expressed in the hippocampus and the cerebellum (PubMed:27472885). Isoform 2: Abundant in lymph node, spleen, thymus and trachea (PubMed:14592415). Isoform 1: Strongly expressed in brain and bone marrow (PubMed:14592415).

亚细胞定位

Cell membrane